Chasteberry - Theoretical Interference with Drug Action
Bromocriptine reduces the level of the hormone prolactin by affecting the pituitary gland. It is sometimes used to treat conditions in which there is too much prolactin, such as certain forms of PMS and infertility.
Theoretical Interference with Drug Action
The herb chasteberry inhibits prolactin secretion and might have unpredictable effects if combined with bromocriptine.1–4
1. Milewicz A, et al. Vitex agnus-castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study. Arzneimittelforschung 43(7): 752–756, 1993.
2. Jarry H, et al. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus-castus: Direct evidence for a dopaminergic principle by the dopamine receptor assay. EYP Clin Endocrinol 102: 448–454, 1994.
3. Sliutz G, et al. Agnus-castus extracts inhibit prolactin secretion of rat pituitary cells. Horm Metab Res 25(5): 253–255, 1993.
4. Schulz V, et al. Rational phytotherapy. New York: Springer-Verlag, 1998: 241–242.
Last reviewed December 2015 by EBSCO CAM Review Board
Last Updated: 12/15/2015