Bipolar disorder (BD) is a mental health disorder. It causes severe swings in mood, energy, and function. People who swing between happy and full of energy to a low mood with a poor temper. It can affect school, work, and personal relations.
Treatment can help to gain better control of symptoms. A combination of medicine and therapy can help. Alternative therapies can’t take the place of traditional medicine. However, some may use them along with standard treatments.
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Talk to your doctor about any supplements or therapy you would like to use. Many can interact with antidepressant medicine. Some herbs and supplements that should be noted include:
A1. Qureshi N, Al-Bedah A. Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat. 2013;9:639-658.
A2. Norelli LJ, Xu C. Manic psychosis associated with ginseng: a report of two cases and discussion of the literature. J Diet Suppl. 2015 Jun;12(2):119-125.
B1. Lin PY, Su KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry. 2007;68:1056-1061.
B2. Berk M, Copolov DL, et al. N-acetyl cysteine for depressive symptoms in bipolar disorder—a double-blind randomized placebo-controlled trial. Biol Psychiatry. 2008 Sep 15;64(6):468-475.
B3. Osuji IJ, Vera-Bolaños E, et al. Pregnenolone for cognition and mood in dual diagnosis patients. Psychiatry Res. 2010;178(2):309-312.
B4. Sarris J, Mischoulon D, Schweitzer I. Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression. J Clin Psychiatry. 2011 Aug 9.
B5. Sarris J, Mischoulon D, et al. Omega-3 for bipolar disorder: a meta-analyses of use in mania and bipolar depression. J Clin Psychiatry. 2012 Jan;73(1):81-86.
B6. Berk M, Dean OM, et al. Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial. BMC Med. 2012 Aug 14;10:91.
B7. Qureshi N, Al-Bedah A. Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat. 2013;9:639-658.
B8. Brown ES, Park J, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology. 2014;39(12):2867-2873.
B9. Rosenblat JD, Kakar R, et al. Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis. Bipolar Disord. 2016 Mar;18(2):89-101.
B10. Fernandes BS, Dean OM, et al. N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis. J Clin Psychiatry. 2016 Apr;77(4):e457-466.
B11. Shakeri J, Khanegi M, et al. Effects of Omega-3 supplement in the treatment of patients with bipolar I disorder. Int J Prev Med. 2016 May 19;7:77.
B12. Vesco AT, Young AS, et al. Omega-3 supplementation associated with improved parent-rated executive function in youth with mood disorders: a secondary analyses of the omega 3 and therapy (OATS) trials. J Child Psychol Psychiatry. 2017 Oct 24.
B13. Mehrpooya M, Yasrebifar F, et al. Evaluating the Effect of Coenzyme Q10 Augmentation on Treatment of Bipolar Depression: A Double-Blind Controlled Clinical Trial. J Clin Psychopharmacol. 2018;38(5):460-466.
Last reviewed March 2019 by EBSCO NAT Review Board
Last Updated: 3/27/2019