Here are the basics about each of the medicines below. Only common problems with them are listed.
Medicines cannot cure scleroderma. They can only manage symptoms.
These drugs are given to try to slow the disease. They work by suppressing the immune system.
Nonbiological DMARDs may include methotrexate and cyclophosphamide. Biologic DMARDs may include antithymocyte globulin, imatinib, or rituximab
Some problems may be:
Some NSAIDs are available as over the counter medicines. This is given as a prescription to deliver a higher dosage. NSAIDs help ease inflammation, swelling, and joint pain.
Some problems may be:
Corticosteroids are strong anti-inflammatory medicines. They are given to ease swelling, inflammation, and joint pain.
Short-term problems may be:
Long-term problems may be:
Calcium-channel blockers can ease symptoms of Raynaud phenomenon by relaxing blood vessels. This allows better blood flow through the fingers, toes, and the tip of the nose. There will be less skin discoloring, numbness, and tingling. They can also lower the risk of sores or ulcers on the fingertips.
Calcium-channel blockers may also be given to treat high blood pressure.
Problems may be:
These medicines are used for Raynaud phenomenon that is not helped by other methods. They are also used to heal sores on the fingers and to treat pulmonary hypertension.
May include bosentan, ambrisentan, or sildenafil
Problems may be:
Blood pressure medicines are given to lower high blood pressure.
May include angiotensin-converting enzyme (ACE) inhibitors or calcium-channel blockers.
Problems may be:
Prostanoids are given to improve blood flow.
Problems may be:
Antibiotics may be given to help treat diarrhea. This is often caused by an overgrowth of bacteria in the small intestine.
Problems may be:
H-2 blockers help ease acid production in the stomach. They may be given to help with heartburn and indigestion.
Problems may be:
Kowal-Bielecka O, Fransen J, et al. Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis. 2017 Aug;76(8):1327-1339.
Localized scleroderma. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/localized-scleroderma. Accessed August 12, 2020.
Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: https://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Accessed August 12, 2020.
Systemic sclerosis. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/systemic-sclerosis. Accessed August 12, 2020.
What is scleroderma? Scleroderma Foundation website. Available at:
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Accessed August 12, 2020.
Last reviewed March 2020 by EBSCO Medical Review Board James P. Cornell, MD