Lyme disease symptoms vary from person to person. It depends on the stage of the infection. Some people may not have symptoms.
These symptoms often develop 3 to 30 days after a tick bite:
A red rash known as erythema migrans (EM) may develop. It starts as a small red spot at the site of the tick bite. The rash expands over a period of days or weeks. It becomes oval-shaped. The rash often looks like a bull’s eye—a red ring surrounding a clear or bluish area with a red center. The size of the rash can range from dime-sized to the entire width of a person’s back. More than one ring may develop. Typically, the rash goes away within 4 weeks.
Lyme Disease Rash
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Many people do not have the rash right away or at all. Or they may have a red rash, without the bull's eye pattern.
Flu-like symptoms may develop. They may occur with or without the rash. They may include muscle and joint aches, headache, fever (a temperature of 100 to103°F or 37.7-39.4°C), stiff neck, swollen glands, and tiredness. These symptoms usually last about 5 to 21 days.
Note: Early symptoms usually happen with the first rash or within about 6 weeks of it. They may go away on their own within a few weeks or months.
Lyme disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/lyme-disease. Accessed November 11, 2021.
Lyme disease symptoms. Lyme Disease.org website. Available at: https://www.lymedisease.org/lyme-basics/lyme-disease/symptoms. Accessed November 11, 2021.
Ross Russell AL, Dryden MS, et.al. Lyme disease: diagnosis and management. Pract Neurol. 2018;18(6):455-464.
Signs and symptoms of untreated lyme disease. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/lyme/signs_symptoms/index.html. Accessed November 11, 2021.
Last reviewed November 2021 by
EBSCO Medical Review Board David L. Horn, MD
Last Updated: 11/11/2021