Brand Name(s):

• Zinplava^®

WHY is this medicine prescribed?    TOP

Bezlotoxumab injection is used to decrease the risk ofClostridium difficileinfection (C. difficileor CDI; a type of bacteria that can cause severe or life-threatening diarrhea) from coming back in people who are at high risk forC. difficileinfection and who are already taking an antibiotic drug to treatClostridium difficile. Bezlotoxumab is in a class of medications called monoclonal antibodies. It works by binding to a C. difficiletoxin to stop its effects on the body.

HOW should this medicine be used?    TOP

Bezlotoxumab comes as a solution (liquid) to be injected intravenously (into a vein) over 60 minutes. Bezlotoxumab is administered as a single dose by a doctor or nurse.

Bezlotoxumab injection does not take the place of antibiotic treatment forC. difficileinfection; continue your antibiotic treatment as directed by your doctor.

Are there OTHER USES for this medicine?    TOP

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?    TOP

Before receiving bezlotoxumab injection,

• tell your doctor and pharmacist if you are allergic to bezlotoxumab, any other medications, or any of the ingredients in bezlotoxumab infusion. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had heart failure.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

What SIDE EFFECTS can this medicine cause?    TOP

What should I do in case of OVERDOSE?    TOP

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?    TOP

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about bezlotoxumab injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

AHFS^® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: February 15, 2019.