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Guggul is a small tree that grows in Southern Asia. The roots make a yellow resin called guggulu that has been used to lower cholesterol and body mass. It can be taken as a pill, powder, or extract.
There are no advised doses for guggul.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
It may be safe for most adults to take guggul for a short time. Some people taking guggul have allergic reactions, skin rash, and itching.C1, C2 Not enough studies have been done to say whether it is safe to take for a long period or during pregnancy or breastfeeding.
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse, such as:C3, C4
A. High Cholesterol
A1. Szapary PO, Wolfe ML, et al. Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. JAMA. 2003 Aug 13;290(6):765-772.
A2. Nohr LA, Rasmussen LB, et al. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther Med. 2009 Jan;17(1):16-22.
B. Metabolic Syndrome
B1. Patti AM, Al-Rasadi K, et al. Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrome. Angiology. 2015 Oct;66(9):856-861.
C1. Kölönte A, Guillot B, et al. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis. 2006 Apr;54(4):226-227.
C2. Salavert M, Amarger S, et al. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis. 2007 May;56(5):286-287.
C3. Hasani-Ranjbar S, Nayebi N, et al. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Curr Pharm Des. 2010;16(26):2935-2947.
C4. Yellapu RK, Mittal V, et al. Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. Can J Gastroenterol. 2011 Mar;25(3):157-160.
Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC Last Updated: 6/22/2020