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Artichoke is a common plant that has been used to help lower cholesterol. It can be cooked and eaten. It can also be taken as an extract, pill, or powder.
300 milligrams of extract, 2 to 3 times per day
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
It is likely safe to eat artichoke. Artichoke may cause allergic reactions in people with certain plant allergies. Not enough studies have been done to say whether it is safe to eat large amounts for a long period.
Talk to your doctor about any supplements or therapy you would like to use. Artichoke supplements can interfere with treatment or make conditions worse, such as:
A. High Cholesterol
A1. Rondanelli M, Giacosa A, et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr. 2013;64(1):7-15.
A2. Wider B, Pittler MH, et al. Artichoke leaf extract for treating hypercholesterolemia. Cochrane Database Syst Rev. 2013;28(3):CD003335.
A3. Rondanelli M, Giacosa A, et al. MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review. Biomed Res Int. 2016;2016:2025687. Epub 2016 Nov 1.
A4. Sahebkar A, Pirro M, et al. Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2017:1-8.
B1. Giacosa A, Guido D, et al. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med. 2015;915087.
C. Metabolic Syndrome
C1. Ebrahimi-Mameghani M, Asghari-Jafarabadi M, et al. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial. J Integr Med. 2018;16(5):329-334.
D. Non-Alcoholic Fatty Liver Disease
D1. Panahi Y, Kianpour P, et al. Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytother Res. 2018;32(7):1382-1387.
Last reviewed March 2019 by EBSCO NAT Review Board Eric Hurwitz, DC Last Updated: 3/2/2019