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Andrographis is a plant commonly used in South Asian medicine. Its leaves are used to treat symptoms of the common cold. It can be taken as a pill or a powder.
400-1200 milligrams once daily
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
It is likely safe to take small amounts of andrographis over a short period of time. Not enough studies have been done to say whether it is safe to use for a long period.
Talk to your doctor about any supplements or therapy you would like to use. Andrographis can interfere with treatment or make conditions worse, such as:
A. Common Cold
A1. Wagner L, Cramer H, et al. Herbal Medicine for Cough: a Systematic Review and Meta-Analysis. Forsch Komplementmed. 2015;22(6):359-368.
B1. Phunikhom K, Khampitak K, et al. J. Effect of Andrographis paniculata Extract on Triglyceride Levels of the Patients with Hypertriglyceridemia: A Randomized Controlled Trial. J Med Assoc Thai. 2015 Jul;98 Suppl 6:S41-S47.
C. Inflammatory Bowel Disease
C1. Tang T, Targan SR, et al. Randomized clinical trial: herbal extract HMPL-004 in active ulcerative colitis – a double-blind comparison with sustained release mesalazine. Aliment Pharmacol Ther. 2011;33(2):194-202.
C2. Ng SC, Lam YT, et al. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2013 Oct;38(8):854-863.
C3. Sandborn WJ, Targan SR, et al. Andrographis paniculate extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98.
C4. Langhorst J, Wulfert H, et al. Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. J Crohns Colitis. 2015 Jan;9(1):86-106. doi: 10.1093/ecco-jcc/jju007. Epub 2014 Nov 28. Review.
D. Multiple Sclerosis
D1. Bertoglio JC, Baumgartner M, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016 May 23;16:77.
E. Rheumatoid Arthritis
E1. Burgos RA, Hancke JL, et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009;28(8):931-946.
F. Rheumatoid Arthritis
F1. Saxena RC, Singh R, et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010;17(3-4):178-185.
F2. Hu XY, Wu RH, et al. Andrographis paniculate (Chuān Xīn Lián) for symptomatic relief of acute respiratory infections in adults and children: A systematic review and meta-analysis. PLoS One. 2017;12(8).
Last reviewed March 2019 by EBSCO NAT Review Board Eric Hurwitz, DC Last Updated: 3/2/2019