Para-aminobenzoic acid (PABA) is a compound found in milk, eggs, grains, and meat. It is best known as the active ingredient in sunscreen. PABA has been used to improve discoloration in skin and hair and to ease digestion. It can be taken as a pill, powder, or extract.
There are no advised doses for PABA. Doses greater than 12 grams per day by mouth have caused severe reactions in some people.
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It is likely safe for most adults to use PABA on the skin and to take by mouth in small doses for a short time, but intestinal symptoms and allergic reactions are possible.B1, B2 High doses may not be safe and should be avoided. Not enough studies have been done to say whether it is safe to take by mouth for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse such as:
A. Peyronie Disease
A1. Hasche-Klünder R. [Treatment of peyronie’s disease with para-aminobenzoacidic potassium (POTOBA) (author’s transl)]. Urologgee A. 1978;17(4):224-227.
A2. Weidner W, Hauck EW, et al. Potassium paraaminobenzoate (POTABA) in the treatment of Peyronie's disease: a prospective, placebo-controlled, randomized study. Eur Urol. 2005 Apr;47(4):530-535; discussion 535-536.
B1. Worobec S, LaChine A. Dangers of orally administered para-aminobenzoic acid. JAMA. 1984 May 11;251(18):2348.
B2. Kantor GR, Ratz JL. Liver toxicity from potassium para-aminobenzoate. J Am Acad Dermatol. 1985 Oct;13(4):671-672.
C1. Clegg DO, Reading JC, et al. Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma. J Rheumatol. 1994 Jan;21(1):105-110.
Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC Last Updated: 6/17/2020