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Hepatitis B Vaccine

(Hep B Vaccine)

What Is Hepatitis B?

Hepatitis B is a disease caused by the hepatitis B virus (HBV). This virus attacks the liver. The disease can cause:

Hepatitis B virus (HBV) is spread through the blood or other body fluids of an infected person.

Most hepatitis B infections clear up without treatment. Others develop into chronic hepatitis B. This can lead to serious complications and death.

What Is the Hepatitis B Vaccine?

The hepatitis B vaccine (HBV) is produced by inserting a gene for HBV into yeast. The yeast is grown, harvested, and purified. The vaccine is given as an injection into the muscle. This is usually given in a series of 3-4 shots during a 6-month period.

Who Should Get Vaccinated and When?


Newborns routinely receive the first dose of the hepatitis B vaccine (HBV) within 24 hours of birth. Two more injections are given to all infants at:

  • 1-2 months
  • 6-18 months

Depending on the type of vaccine, some babies may receive 4 doses.

Children and teens (aged 18 years or younger) who have not been immunized as babies can also get the vaccine. For children aged 11-15 years, there is a 2-dose series available.


It is recommended that adults (aged 18 years or older) get vaccinated if they are at high risk for hepatitis B. High risk includes:

  • Sexual activity outside a long-term, mutually monogamous relationship
  • Getting treatment or counseling for a sexually transmitted disease (STD)
  • Sex without using a condom including vaginal and anal sex
  • Men who engage in sexual activity with other men
  • Being an IV drug user or having a history of injecting drugs
  • Having chronic kidney disease or HIV
  • Liver disease, including hepatitis C virus infection, cirrhosis, fatty liver disease, alcoholic liver disease, autoimmune hepatitis, and an alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level greater than twice the upper limit of normal
  • Undergoing dialysis
  • Having diabetes if you are younger than 60 years old
  • Having a job where you might be exposed to HBV-infected blood or body fluids
  • Working or living in an institution for the developmentally disabled
  • Living with or working with people who have chronic HBV infection
  • Traveling to areas where there is a high rate of HBV infection

What Are the Risks Associated With the Hepatitis B Vaccine?

All vaccines are capable of causing serious problems, such as a severe allergic reaction.

Most people who get the hepatitis B vaccine do not have problems. Some may have mild problems, including soreness where the shot was given, fatigue, nausea, diarrhea, or fever.

Acetaminophen is sometimes given to reduce pain and fever that may occur after getting a vaccine. In infants, the medication may weaken the vaccine's effectiveness. Discuss the risks and benefits of taking acetaminophen with the doctor.

Who Should Not Get Vaccinated?

You should not get the vaccine if you:

What Other Ways Can Hepatitis B Be Prevented Besides Vaccination?

Other than getting the hepatitis B vaccine (HBV), the best methods of preventing an HBV infection include:

What Happens in the Event of an Outbreak?

In the event of an outbreak, all at-risk people should be offered the vaccine.


Centers for Disease Control and Prevention

National Institute of Diabetes and Digestive and Kidney Diseases


2015 Sexually transmitted diseases treatment guidelines. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/std/tg2015/default.htm. Updated January 25, 2017. Accessed October 2, 2017.

Hepatitis B FAQs for the public. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/hepatitis/hbv/bfaq.htm. Updated May 23, 2016. Accessed October 2, 2017.

Hepatitis B vaccination. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/vaccines/vpd/hepb/index.html. Updated July 9, 2015. Accessed October 2, 2017.

Hepatitis B vaccine recombinant. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T356382/Hepatitis-B-Vaccine-Recombinant. Updated August 7, 2017. Accessed October 2, 2017.

Hepatitis B VIS. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/vaccines/hcp/vis/vis-statements/hep-b.html. Updated October 18, 2016. Accessed October 2, 2017.

Immunization schedules. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/vaccines/index.html. Updated April 21, 2017. Accessed May 22, 2017.

Viral hepatitis. Centers for Disease Control and Prevention website. Available at: https://www.cdc.gov/hepatitis/index.htm. Updated August 17, 2017. Accessed October 2, 2017.

Last reviewed September 2018 by EBSCO Medical Review Board Marcin Chwistek, MD  Last Updated: 2/8/2017