Supplement Forms/Alternate Names:
Manganese is a metal found in the body that acts as an antioxidant to help slow damage to cells. It has been used to ease pain in the muscles and joints. Manganese has also been used to help control blood glucose and ease menstrual symptoms. It can be taken as a pill or powder. It can also be injected into the bloodstream by a healthcare provider.
50 milligrams 1 to 2 times daily
What Research Shows
Not Enough Data to Assess
- Knee osteoarthritis A1, A2
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
It is likely safe to take manganese in small doses for a short time. It may be unsafe for most adults to take more than 11 milligrams daily. Not enough studies have been done to say whether it is safe to take for a long period.
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse such as:
- People with Parkinson disease should talk to their doctors before taking manganese. It may be toxic.
A1. Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH 122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000;8(5):343-350.
A2. Whelan AM, Jurgens TM, et al. Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials. Ann Pharmacother. 2006 May;40(5):836-849.
Last reviewed March 2020 by EBSCO NAT Review Board Eric Hurwitz, DC Last Updated: 6/29/2020