Acetaminophen is a common over-the-counter (OTC) pain medication. Tylenol is one brand of this medication. Acetaminophen poisoning is an overdose of this medication. It can cause damage to the liver.
The overdose may happen as an accident or an intentional overdose. This can be a serious condition that will need medical care.
Acetaminophen poisoning may occur as a result of one large dose or several small overdoses over a long period of time. An overdose of acetaminophen can result from:
Certain chronic diseases can make you more vulnerable to this type of overdose. For example, people with liver damage can have acetaminophen poisoning at lower doses. Poisoning can also happen if acetaminophen is taken along with other substances that harm the liver, such as alcohol.
Factors that may increase your chance of acetaminophen poisoning include:
At first, a person with acetaminophen poisoning may have no symptoms.
When symptoms develop, they can include:
Jaundiced Skin from Damaged Liver
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You will be asked about your symptoms and medical history. A physical exam will be done. Blood tests may be done to:
Talk with your doctor about the best treatment plan for you. Treatment options include:
People with low levels of acetaminophen in the blood may only need to be monitored. If symptoms develop or worsen, then other treatments may be started.
Activated charcoal is taken by mouth. The charcoal can help block the absorption of acetaminophen. It will not affect the medication that is already in the body.
N-acetylcysteine is an antidote to acetaminophen poisoning. It can prevent damage to the liver. It may be given by mouth or IV. The earlier this antidote is delivered, the better the outcome will be.
To help reduce your chance of acetaminophen poisoning:
American Association of Poison Control Centers
Healthy Children—American Academy of Pediatrics
Canadian Institute for Health Information
Safe Kid—Children's Health & Safety Association
Acetaminophen poisoning. DynaMed website. Available at:
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Updated January 13, 2015. Accessed September 3, 2015.
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8/8/2011 DynaMed's Systematic Literature Surveillance
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McNeil Consumer Healthcare announces plans for new dosing instructions for Tylenol products. Johnson & Johnson website. Available at: http://www.jnj.com/connect/news/all/mcneil-consumer-healthcare-announces-plans-for-new-dosing-instructions-for-tylenol-products. Accessed September 3, 2015.
Last reviewed September 2015 by James Cornell, MD
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