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Mild cognitive impairment–amnestic type (MCI-AT) is mild, repeated memory loss. It lies between the normal memory loss of aging and the more serious conditions of dementia and Alzheimer's disease. MCI-AT only involves problems with memory.
People with MCI-AT who are over age 65 have a higher chance of developing dementia and Alzheimer's. However, many people with MCI-AT never develop these disorders. Some even return to normal.
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The causes are not clear. However, genetic factors may be a cause.
Factors that may increase your chance of developing MCI-AT include:
Research also suggests that these may be risk factors for MCI-AT:
The main symptom is frequent, ongoing memory loss beyond what is normally expected for your age. That means having more than small lapses of memory. If you have MCI-AT, you may:
You will be asked about your symptoms and medical history. A physical exam will be done. The doctor may also talk with family members and caregivers. Tests may include:
Imaging tests take pictures of internal bodily structures. This can be done with:
Treatment is focused on:
Researchers are currently studying the effects that several medications may have on slowing cognitive decline. These include:
To help reduce your chance of developing MCI-AT:
American Psychiatric Association
National Institute on Aging
The Alzheimer Society of Canada
Birks J, Flicker L. Donepezil for mild cognitive impairment. Cochrane Database Syst Rev. 2006;3:CD006104.
DeKosky ST, Williamson JD, et al. Ginko biloba for prevention of dementia: A randomized controlled trial. JAMA. 2008;300(19):2306-2308.
Feldman HH, Jacova C. Mild cognitive impairment. Am J Geriatr Psychiatry. 2005;13(8):645-655.
Gauthier S, Reisberg B, et al. Mild cognitive impairment. Lancet. 2006;367(9518):1262-1270.
Institute for the Study of Aging and International Longevity Center–USA (March 2001). Achieving and Maintaining Cognitive Vitality With Aging: A Workshop Report. New York, NY.
Mild cognitive impairment (MCI). EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T113612/Mild-cognitive-impairment-MCI. Updated May 3, 2017. Accessed October 2, 2017.
Petersen RC. Mild cognitive impairment: Current research and clinical implications. Semin Neurol. 2007;27(1):22-31.
Petersen RC, Roberts RO, et al. Mild cognitive impairment: Ten years later. Arch Neurol. 2009;66(12):1447-1455.
Petersen RC, Smith GE, et al. Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology. 1999;56(3):303-308.
Last reviewed September 2018 by EBSCO Medical Review Board Rimas Lukas, MD Last Updated: 9/30/2013