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(Androblastoma; Sertoli-Leydig Cell Tumor of the Ovary)
Amanda Barrett, MA
An arrhenoblastoma is a rare type of ovarian tumor. This tumor primarily secretes the male sex hormone, testosterone, and rarely the female sex hormone, estrogen. It accounts for less than 0.5% of all ovarian tumors.
Arrhenoblastomas are generally benign, meaning they do not normally spread beyond the ovary. However, they may cause male physical characteristics to develop in women, such as facial hair and a deepening voice. If you suspect you have this condition, contact your doctor immediately.
If you experience any of these symptoms, do not assume it is due to an arrhenoblastoma. These symptoms may be caused by other, less serious health conditions. If you experience any one of them, see your physician.
In many cases, infrequent menstrual periods or cessation of menstrual periods is the only symptom
In up to one in three patients, arrhenoblastoma is accompanied by masculinization, including any of the following:
Your doctor will ask about your symptoms and medical history, and perform a physical exam. He or she will also test your levels of male hormones (such as testosterone and androsterone) to see if they are excessive.
Tests may include the following:
Blood tests of hormone levels (including testosterone, DHEA, CD56, and progesterone levels)—to detect if male hormones are high
—to identify the location, size, and shape of the tumor
Treatment involves surgery to remove one or both ovaries. This procedure is usually successful in returning normal menstruation (in premenopausal women) and ceasing masculinization. If the tumor is late stage and particularly aggressive (which is rare),
chemotherapy, or both, in addition to surgery, may be needed.
There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. To learn more about risk factors for ovarian cancers in general, see the fact sheet on
for more information.
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