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Arrhenoblastoma

(Androblastoma; Sertoli-Leydig Cell Tumor of the Ovary)

Definition

An arrhenoblastoma is a rare type of ovarian tumor. This tumor primarily secretes the male sex hormone, testosterone, and rarely the female sex hormone, estrogen.

Arrhenoblastomas are generally benign, meaning they do not normally spread beyond the ovary.

Arrhenoblastoma

Ovarian Cancer
Copyright © Nucleus Medical Media, Inc.

Causes    TOP

The cause of arrhenoblastoma is unknown.

Risk Factors    TOP

Arrhenoblastomas are most common in young women between the ages of 20 and 30 years of age. However, they can occur at any age, including in toddlers, young girls, and postmenopausal women.

Arrhenoblastoma mare also be a rare complication of pregnancy.

Symptoms    TOP

In many cases, infrequent menstrual periods or cessation of menstrual periods is the only symptom.

In up to one in three patients, arrhenoblastoma is accompanied by masculinization, including any of the following:

Diagnosis    TOP

You will be asked about your symptoms and medical history. A physical exam will be done.

Your bodily fluids may be tested. This can be done blood tests of hormone levels.

Images may be taken of your bodily structures. This can be done with ultrasound.

Pelvic Ultrasound

Pelvic Ultrasound
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Treatment    TOP

Treatment involves surgery to remove one or both ovaries. This procedure is usually successful in returning normal menstruation (in premenopausal women) and ceasing masculinization. If the tumor is late stage and particularly aggressive (which is rare), radiation therapy, chemotherapy, or both, in addition to surgery, may be needed.

Prevention    TOP

There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown.

RESOURCES:

The Endocrine Society
http://www.endo-society.org
Ovarian Cancer National Alliance
http://www.ovariancancer.org

CANADIAN RESOURCES:

Canadian Cancer Society
https://www.cancer.ca
Ovarian Cancer Canada
http://www.ovariancanada.org/

References:

Chen F, Sheu B, et al. Sertoli-leydig cell tumor of the ovary. J Formos Med Assoc. Available at:
...(Click grey area to select URL)
Accessed October 29, 2014.
Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002;87:49-56.
Colombo N, Parma G, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;20:2944-2951.
Leydig cell tumor. EBSCO DynaMed website. Available at:
...(Click grey area to select URL)
Updated February 28, 2011. Accessed October 29, 2014.
McCluggage WG, McKenna M, et al. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord stromal tumor. Int J Gyn Pathol. 2007;26:322-327.
Sachdeva P, Arora R, et al. Cell tumor: a rare ovarian neoplasm. Gynecologic Endocrinology. 2008;24(4):230-234.
Sex cord-stromal tumors. Johns Hopkins Pathology website. Available at:
...(Click grey area to select URL)
Updated June 25, 2001. Accessed October 29, 2014.
Last reviewed October 2014 by Andrea Chisholm, MD
Last Updated: 1/15/2014