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Conditions InDepth: Epilepsy

Epilepsy is a chronic condition produced by temporary changes in the electrical function of the brain, causing seizures, which can affect awareness, movement, or sensation.

Seizures occur when clusters of nerve cells in the brain, called neurons, signal or communicate with each other abnormally. During a seizure, the neurons' normal pattern of activity is disturbed. It causes them to fire as many as 500 times per second instead of the normal rate of about 80 times per second. This can cause strange sensations, emotions, and behavior, or convulsions, muscle spasms, and/or loss of consciousness.

Neurons in Nerve Tissue

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A diagnosis of epilepsy is usually not made until a person has a seizure more than once without a preventable cause.

The causes of abnormal brain wiring and imbalance of neurotransmitters are numerous. They can include:

In many cases, the exact cause of epilepsy is not known.

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References:

Berkow R. The Merck Manual of Medical Information. 17th ed. New York, NY: Simon and Schuster; 2000.
Epilepsy in adults. EBSCO DynaMed website. Available at:
...(Click grey area to select URL)
Updated February 18, 2013. Accessed February 22, 2013.
Epilepsy in children. EBSCO DynaMed website. Available at:
...(Click grey area to select URL)
Updated November 19, 2012. Accessed February 22, 2013.
Lowenstein DH. Seizures and epilepsy. In: Longo DL, Fauci AS, et al, eds. Harrison's Principles of Internal Medicine. 18th ed. New York, NY: McGraw-Hill; 2012.
NINDS Epilepsy information page. National Institute of Neurological Disorders and Stroke website. Available at:
...(Click grey area to select URL)
Updated February 21, 2013. Accessed February 22, 2013.
What is epilepsy? Epilepsy Foundation website. Available at:
...(Click grey area to select URL)
Accessed February 22, 2013.
Last reviewed March 2014 by Rimas Lukas, MD
Last Updated: 05/06/2014