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Type 2 Diabetes

(Diabetes Mellitus Type 2; Insulin-Resistant Diabetes; Diabetes, Type 2)

Definition

Glucose comes from the breakdown of food. It is the body's energy source. It can pass from the blood to cells with the help of a hormone called insulin. Without insulin, glucose will build up in the blood and cause hyperglycemia. Otherwise known as high blood glucose. At the same time, your body's cells are starved for glucose (energy).

A lack of insulin or a resistance to insulin causes diabetes. In type 2 diabetes the body is resistant to high levels of insulin. There is plenty of insulin in the body but the cells are unable to use it.

High blood sugar levels over a long period of time can damage vital organs. This can include the kidneys, eyes, and nerves.

The Pancreas

Insulin is made in the pancreas.
© 2009 Nucleus Medical Media, Inc.

Causes    TOP

Two conditions contribute to hyperglycemia in type 2 diabetes:

  • Insulin resistance related to excess body fat
  • Body's failure to make an adequate amount of insulin

Risk Factors    TOP

Factors that increase your chance for type 2 diabetes include:

  • Obesity or being overweight (especially excess weight in the upper body and abdomen)
  • History of impaired glucose tolerance
  • Race: African American, Hispanic, Native American, Asian American, or Pacific Islander
  • Lack of physical activity
  • Sleep difficulties
  • Family members with type 2 diabetes
  • Age: 40 years or older and younger individuals who are obese and belong to vulnerable ethnic groups
  • Low birth weight
  • Sex: more common in older women than men
  • History of gestational diabetes
  • Endocrine disorders ( Cushing’s syndrome, hyperthyroidism, acromegaly, polycystic ovary syndrome, pheochromocytoma, glucagonoma)
  • Medicines ( pentamidine, nicotinic acid, glucocorticoids, thiazide)

A study has reported that having a high intake of certain foods can also put you at risk. This includes food such as red meat, low-fiber bread, eggs, and cheese.

Symptoms    TOP

You may not have symptoms for years. Symptoms due to high blood sugar or diabetic complications may include:

  • Increased urination
  • Extreme thirst
  • Hunger
  • Fatigue
  • Blurry vision
  • Irritability
  • Frequent or recurring infections
  • Poor wound healing
  • Angina
  • Painful leg cramps when walking
  • Numbness or tingling in the hands or feet
  • In women: frequent vaginal yeast infections
  • Problems with gums
  • Itching
  • Impotence

Diagnosis    TOP

The doctor will ask about your symptoms and medical history. You will also be asked about your family history. A physical exam will be done.

Diagnosis is based on the results of blood tests and other criteria, including:

  • Symptoms of diabetes and a random blood test revealing a blood sugar level greater than or equal to 200 mg/dL [11.1 mmol/L]
  • Blood sugar tests after you have not eaten for eight or more hours (called fasting blood sugar) revealing blood sugar levels greater than or equal to 126 mg/dL (7.0 mmol/L) on two different days
  • Glucose tolerance test measuring blood sugar two hours after you consume glucose with a measurement greater than or equal to 200 mg/dL (11.1 mmol/L)

mg/dL=milligrams per deciliter of blood; mmol/L=millimole per liter of blood

Treatment    TOP

Treatment aims to:

  • Maintain blood sugar at levels as close to normal as possible
  • Preventing or delaying complications (regular medical care is important for this)
  • Control other conditions that you may have like high blood pressure and high cholesterol

Diet

Weight Loss

If you are overweight, talk to your doctor about a reasonable weight goal. You and your doctor can develop a safe diet program for you. Weight loss will help your body respond better to insulin.

Group education may help people recently diagnosed with their goals in weight loss.

Exercise

Physical activity:

  • Can make the body become more sensitive to insulin
  • Will help you reach and maintain a healthy weight
  • Can lower the levels of fat in your blood
  • Has been found to improve blood sugar control— Aerobic, fitness, and resistance training can help to improve hemoglobin A1c (HbA1c) blood levels. HbA1c is the average blood sugar level over 3 months. This is a measure of your average blood glucose levels over the past three months. Researchers have also found that long-term strength and endurance training may improve HbAIc, even in the absence of weight loss.

Talk to your doctor about any restrictions. Work with your doctor to make an activity plan. Even a brief counseling session may help to increase your activity levels.

Diabetes is a risk factor for heart disease. Exercising can help to reduce your risk for heart disease.

Oral Medication

Medications taken by mouth may be used to lower blood sugar:

  • Metformin: a class of drug that reduces the body's production of glucose. It also makes the body more sensitive to insulin. This combination will help keep blood sugar levels within the normal limits.
  • Drugs that prompt the cells in the pancreas to make more insulin (eg, sulfonylureas [ glyburide, tolazamide ], dipeptidyl peptidase-4 inhibitors [ saxagliptin, sitagliptin ], repaglinide [Prandin])
    • The FDA has warned that sitagliptin may increase the risk of acute pancreatitis.
  • Insulin sensitizers—a class of drugs that help the body better use insulin (eg, pioglitazone)
  • Starch blockers—a class of drugs (eg, acarbose, miglitol) that lessen glucose absorption into the bloodstream

Injectable medication such as:

  • Incretin-mimetic (eg, exenatide) stimulate the pancreas to produce insulin and suppress appetite often leading to weight loss. (twice daily injections)
  • Amylin analogues (eg, pramlintide) replace a protein that is normally produced by the pancreas and is low in type 2 diabetes (injection before each meal)

Talk to your doctor about your drug program.

Insulin

In some cases the body does not make enough insulin. Insulin injections may be needed.

This is needed when blood sugar levels are not kept low enough with lifestyle change and medicine

Blood Glucose Testing

Checking blood glucose levels during the day can help you stay on track. It will also helps your doctor determine if you treatment is working. Testing is easy with a blood glucose monitor. Keeping track of blood glucose levels is especially important if you take insulin. Frequency of blood glucose testing is determined by how well your blood sugar control is doing.

The HbA1c may also be done at your doctor's office. Doctors advise that most keep their HbA1c levels below 7% (American Diabetes Association recommendation). This level has been shown to lead to fewer diabetic complications.

Regular blood sugar testing may not be needed in patients with type 2 diabetes. It may not be needed for those whose condition is under reasonably good control without insulin. Talk with your doctor before stopping blood sugar monitoring.

Alternative Therapies

One study focused on people with a specific type 2 diabetes. When given vitamin E they showed a decrease in the rates of heart problems.

If you are diagnosed with type 2 diabetes, follow your doctor's instructions.

Prevention    TOP

Lifestyle changes seem to be most effective. To reduce your chances of developing type 2 diabetes:

  • Participate in regular physical activity.
  • Maintain a healthy weight.
  • Drink alcohol in moderation (two drinks per day for a man, and one drink per day for a woman)
  • Eat a well-balanced diet:
    • Get enough fiber
    • Avoid fatty foods
    • Limit sugar intake

RESOURCES:

American Diabetes Association
http://www.diabetes.org/
National Diabetes Information Clearinghouse
http://diabetes.niddk.nih.gov

CANADIAN RESOURCES:

Canadian Diabetes Association
http://www.diabetes.ca
Team Diabetes Canada
Canadian Diabetes Association
http://www.diabetes.ca/section_donations/TeamDiabetesIndex.asp

References:

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11/29/06 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Lindstrom J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemio K, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet . 2006;368:1673-1679.
9/19/06 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Thomas DE, Elliott EJ, Naughton GA. Exercise for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews . 2006;CD002968.
6/1/2007 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med . 2007 May 21. [Epub ahead of print]
7/13/2007 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Farmer A, Wade A, Goyder E, et al. Impact of self-monitoring of blood glucose in the management of patients with non-insulin treated diabetes: open parallel group randomised trial. BMJ . 2007 Jun 25. [Epub ahead of print]
12/13/2007 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Milman U, Blum S, Shapira C, et al. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype. A prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol . 2007 Nov 21. [Epub ahead of print]
2/13/2008 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : For safety, NHLBI changes intensive blood sugar treatment strategy in clinical trial of diabetes and cardiovascular disease. NIH News. National Institutes of Health website. Available at: http://www.nih.gov/news/health/feb2008/nhlbi-06.htm . Accessed February 13, 2008.
2/21/2008 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Major international diabetes study does not confirm increased risk of death reported by US trial. Action in Diabetes and Vascular Disease: PreteraAx and DiamicroN MR Controlled Evaluation (ADVANCE) website. Available at: http://www.advance... . Accessed February 21, 2008.
2/28/2008 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Davies MJ, Heller S, Skinner TC, et al. Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial. BMJ . 2008 Feb 14. [Epub ahead of print]
2/28/2008 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Christian JG, Bessesen DH, Byers TE, Christian KK, Goldstein MG, Bock BC. Clinic-based support to help overweight patients with type 2 diabetes increase physical activity and lose weight. Arch Intern Med . 2008;168:141-146.
6/18/2008 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med . 2008;358:2560-2572. Epub 2008 Jun 6.
2/24/2009 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Liese AD, Weis KE, Schulz M, Tooze JA. Food intake patterns associated with incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2009;32:263-268. Epub 2008 Nov 25.
5/11/2009 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Loimaala A, Groundstroem K, Rinne M, et al. Effect of long-term endurance and strength training on metabolic control and arterial elasticity in patients with type 2 diabetes mellitus. Am J Cardiol. 2009;103:972-977.
8/19/2009 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Li TY, Brennan AM, Wedick NM, Mantzoros C, Rifai N, Hu FB. Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes. J Nutr. 2009;139:1333-1338.
10/12/2009 DynaMed Systematic Literature Surveillance http://www.dynamicmedical.com/what.php : Crandall JP, Polsky S, Howard AA, et al. Alcohol consumption and diabetes risk in the Diabetes Prevention Program. Am J Clin Nutr. 2009;90:595-601.
11/20/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Lund SS, Tarnow L, Frandsen M, et al. Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial. BMJ. 2009;339:b4324.
12/21/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2009 Nov 12.
Last reviewed November 2009 by Bridget Sinnott, MD, FACE
Last Updated: 12/21/2009

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