Tuberculosis (TB) is an infection. TB may be either active or latent. Latent forms can stay in your body and not make you sick. Latent TB may become active if you are ill, have a weakened immune system or for no known reason.
TB infection most is most common in the lungs, but it can occur in other places in the body.
TB is a highly contagious disease caused by a specific bacteria (
Mycobacterium bovis). It is transmitted by air from one person to another. This can happen during coughing, sneezing, or talking. Once airborne, the bacteria can be breathed in by other people causing exposure or active infection. You can only pass the infection to other people if you have active TB.
Pathway to the Lungs
is inhaled through the mouth and nose and travels down into the lungs causing TB.
Active or latent TB may be found during a routine check-up.Your doctor will ask about your symptoms and medical history, including if you think you were exposed to TB. A physical exam will be done. Tests that can detect the disease include:
Skin test (PPD or Mantoux test)
If you have symptoms that indicate active TB, your doctor may do the following tests:
Medication can keep TB from becoming active. It can also help cure active TB. It is very important that you take all the medication exactly as prescribed. Take all the medication, even if the symptoms go away. If you do not finish your medication, you may relapse or develop drug-resistant TB. This form is very difficult to cure.
For Latent TB
Inactive (latent) TB will have a positive skin test but you will have no symptoms. You will need to take medication to prevent active TB. You may need to take this medication for a 3-9 month period. Again, it is important to take all the medication as recommended to prevent drug-resistant TB.
For Active TB
Your doctor will give you a combination of drugs. Continue with medication until your doctor tells you to stop. Treatment for active TB typically lasts six months or longer.
You will need to take special steps to prevent spreading TB to others. You may be asked to stay home or stay away from crowded public places. Make sure to cover your mouth whenever you cough. You can resume your normal activities after your doctor says that you are no longer infectious.
Hawkridge T, Mahomed H. Prospects for a new, safer and more effective TB vaccine.
Paediatr Respir Rev. 2011 Mar;12(1):46-51.
Active tuberculosis. EBSCO DynaMed website. Available at: ...(Click grey area to select URL) Updated August 22, 2013. Accessed September 3, 2013.
Latent Tuberculosis. EBSCO DynaMed website. Available at: ...(Click grey area to select URL) Updated March 21, 2013, 2013. Accessed September 3, 2013.
Tuberculosis (TB). Centers for Disease Control and Prevention website. Available at: ...(Click grey area to select URL) Updated March 13, 2012. Accessed September 3, 2013.
12/16/2011DynaMed's Systematic Literature Surveillance
: Sterling T, Villarino E, Borisov A, et al. Three months of rifapentine and isoniazid for latent tuberculosis infection.
N Engl J Med.